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بررسی اثر بخشی گاباپنتین خوراکی بر شدت درد بیماران مبتلا
به کمردرد حاد
Pappoti و همکاران در تحقیقات خود عدم
بیان ژن تیروگلوبولین را به‏عنوان عامل بروز
تیروئید فولیکولار مطرح می­کنند.
در مورد علت بروز تیروئید فولیکولار در جنین­هایی که در معرض
دارو­های ضد­صرع از جمله گاباپنتین قرار
گرفته­اند مطالعه‏ای انجام نشده است
و احتمال دارد گاباپنتین نیز با اثر در بیان این ژن سبب
بروز تیروئید فولیکولار شود، که
این مطلب نیاز به بررسی بیشتر و دقیق­تری دارد.
31 نوجوان (24 دختر و 7 پسر) ارزیابی پایه بر اساس معیارهای YMRS، BDI، HARS و CGIرا کامل کردند و
به طور تصادفی در یکی از گروه­های درمانی لیتیوم با گاباپنتین (16 نفر) یا
لیتیوم با دارونما (15 نفر) برای 8
هفته قرار گرفتند. تفاوت آماری
معنی­داری در سن، جنس و میانگین
نمرات چهار معیار فوق در سطح پایه بین دو گروه وجود نداشت.
تغییرات از پایه برای دو گروه درCGI HARS ،BDI و YMRS بعد از 8 هفته معنی­دار بود ولی تفاوت
بین دو درمان از نظر آماری معنی­دار نبود (جدول 1).

طی یک تحقیق مشخص کرد گاباپنتین تاثیری بر افسردگی ندارد .

افرادی که از دارو های ضد افسردگی یا آرام بخش استفاده می کنند.
گاباپنتن ممکن است باعثافزایش آزادسازی GABAاز
محل های غیروزیکولی شود. Bastaki و همکاران در تحقیقات خود به کاهش سطح سرمی اسیدآمینه متیونین در
موش­های تحت درمان با لاموتریژین پی بردند.

این اسیدآمینه یکی از آمینواسید­های ضروری بوده و کاهش سطح سرمی آن منجر
به بروز ناهنجاری در جنین می­شود .
همچنین از تعداد کل 111 جنین مربوط به گروه تجربی
I در 5 جنین (5/4 درصد)، از تعداد کل 100 جنین مربوط به گروه تجربی II در
5 جنین (5 درصد) و از تعداد کل 99 جنین
مربوط به گروه تجربیIII در 6 جنین (06/6 درصد) تیروئید
فولیکولار مشاهده گردید (شکل 2).

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