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مطالعه برخی اثرات تراتوژنیک داروی گاباپنتین
بر جنین‌ موش نژاد Nmri
قطعا هر گونه تغییر در دوز دارو و قطع دارو باید تحت نظر پزشک معالج باشد و این مقاله ها صرفا
جهت اطلاعات ، بالا بردن اطلاعات عمومی بیماران نوشته شده اند.
در هنگام قطع گاباپنتین نیز بهتر است دارو را ناگهانی قطع نکنیم.
بنابراین هنگام کاهش میزان دارو ، ابتدا از مخلوط کپسول 300میلی
گرمی و 100 میلی گرمی استفاده می‌کنیم و سپس آنها را به 100 میلی گرم
سه بار در روز بعد 100 میلی گرم دو بار در
روز و در نهایت 100 میلی گرم یه بار در روز و
سپس قطع می کنیم . در درمان با گاباپنتین معمولا ابتدا با دوز 100 میلی گرم شروع می کنیم و سپس روزانه 100 میلی گرم دارو به بیمار اضافه می شود
و پس از سه روز برحسب تحمل بیمار دوز دارو را به 300 میلی گرم
در روز می رسانند.
با وجود این که تفاوت میانگین وزن دو گروه در هفته­ی هشتم معنی­دار بوده است، میانگین تغییر وزن از پایه تا هفته­ی هشتم بین
دو گروه معنی­دار نبوده است. افزایش وزن در هر
گروه با عارضه­ی افزایش وزن به همراه لیتیوم قابل توجیه
است. درمان دارویی صرع در دوران بارداری همیشه با
عوارض فراوانی همراه بوده و در
چنین مادرانی جنین بیشتر در معرض بروز ناهنجاری­های مختلف می­باشد
(16 و 17). یکی از جدیدترین داروهایی که امروزه در درمان صرع استفاده می­شود گاباپنتین می­باشد .


یک بررسی در سال 2009 نشان داد که گاباپنتین ممکن است مصرف مواد مخدر را
بعد از جراحی کاهش دهد ، اما به درد مزمن بعد از جراحی کمک نمی کند.
به نظر می رسد گاباپنتین به اندازه پرگابالین برای
درد نوروپاتیک موثر است. عوارض جانبی جدی شامل افزایش خطر خودکشی ، رفتار پرخاشگرانه
و واکنش های دارویی است. شایعترین عوارض جانبی
گاباپنتین شامل سرگیجه ، خستگی ، خواب آلودگی ، آتاکسی ، ورم محیطی (تورم اندام ها) ، نیستاگموس و لرزش است.
هرگز نباید مصرف این دارو را ناگهان متوقف کنید چرا که باعث
علائم قطع مصرف دارو می‌شود.
در صورتی که یک نوبت گاباپنتین را فراموش کردید هر چه سریع تر به محض این که به یاد آوردید مصرف کنید.

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